The glomerular basement membrane gbm is a product of the fusion of the basement membrane produced by endothelial cells and podocytes described below. At higher magnification a. As the glomerulus matures and podocytes begin to synthesize the gbm matrix there is a switch to the production of a3a4a5 type iv collagen which becomes the major type iv collagen expressed in the gbm and some tubular basement membranes such as the distal tubules.
basement membrane glomerulus histology
The glomerular basement membrane gbm is the extracellular matrix component of the selectively permeable glomerular filtration barrier gfb that separates the vasculature from the urinary space.
Basement membrane glomerulus histology. A routine stain on kidney biopsies. Surgical pathology histology date. Glomerular basement membrane gbm. Normally 250 380 nm composed of type iv collagen laminin polyanionic proteoglycans mostly heparan sulfate fibronectin and entactin type iv collagen forms suprastructure to which other glycoproteins attach.
The glomerular basement membrane gbm of the kidney is the basal lamina layer of the glomerulusthe glomerular endothelial cells the gbm and the filtration slits between the podocytes perform the filtration function of the glomerulus separating the blood in the capillaries from the filtrate that forms in bowmans capsule. Note the basement membrane surrounded by podocyte processes. The released aldehydes reduce. In the center a mesangial area in which the nucleus of a mesangial cell by its location is recognized it is surrounded by three capillaries.
Basalmembran im elektronenmikroskop auf den seiten des em atlas im internet. April 2018 um 0709 uhr bearbeitet. The gbm is a fusion of the endothelial cell and podocyte basal. Using tem one can see that the gbm is trilaminar ie three layered and these components include from the endothelial to the podocyte aspect the lamina rara interna lamina densa and lamina rara externa.
The gbm lies between and is initially synthesized by the glomerular endothelial cells that line the glomerular capillaries and the podocytes also called visceral epithelial cells that sit on the. Staining manual connective tissue page. Lamina lucida of basement membrane. The reason for this switch and mechanism of gbm turnover is poorly understood but may be related to increased resistance of.
This part of the filtration. Die glomerulaere basalmembran kurz gbm ist eine form der basalmembran die man in den glomeruli der niere antrifft. For demonstrating the basement membrane of the glomerulus in the kidney. Wichtiger hinweis zu diesem artikel diese seite wurde zuletzt am 28.
The periodic acid oxidizes the carbohydrate components of the basement membrane which produce aldehydes. 1 of 2 basement membranes jones methenamine silver purpose. Zusammen mit den podozyten und endothelzellen des glomerulus bildet die glomerulaere basalmembran die blut harn schrankesie entsteht durch die fusion der laminae densae der beiden basallaminae denen die. Composed of 3 alpha chains.
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